Anti-cancer Pharmaceuticals White Powder Inhibitor Drug Nexavar
Synonyms: SORAFENIB TOSYLATE;Sorafenib & its
4-Methylbenzenesulfonate;Sorafenib Tosylate (Nexavar);Sorafenib
Product Categories: Bay 43-9006
Usage Sorafenib Tosylate (Bay 43-9006, Nexavar) is a small
molecular inhibitor of VEGFR, PDGFR, c-Raf and B-Raf with IC50s of
18 nM, 10 nM, 3 nM and 15 nM, respectively.
Usage Sorafenib Tosylate (Bay 43-9006) is a multikinase inhibitor
of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM,
Sorafenib is a kinase inhibitor drug approved for the treatment of
primary kidney cancer (advanced renal cell carcinoma), advanced
primary liver cancer (hepatocellular carcinoma), and radioactive
iodine resistant advanced thyroid carcinoma.
At the current time sorafenib is indicated as a treatment for
advanced renal cell carcinoma (RCC), unresectable hepatocellular
carcinomas (HCC) and thyroid cancer
|product Name||Sorafenib tosylate|
|CAS Registry Number||475207-59-1;4750207-59-1|
toluenesulfonic Sorafenib is a novel multi-target anticancer drugs,
can act simultaneously on tumor cells and tumor blood vessels. It
has a dual The anti-tumor effect: either by blocking the RAF / MEK
/ ERK-mediated cell signaling pathways and direct inhibition of
tumor cell proliferation, but also By inhibiting VEGF and
platelet-derived Health growth factor (PDGF) receptors and block
the formation of tumor angiogenesis, indirectly inhibit the growth
of tumor cells
Sorafenib is used for:
Treating certain types of kidney, liver or thyroid cancer. It may
also be used for other conditions as determined by your doctor.
Sorafenib is a multikinase inhibitor. It works by helping to stop
cancer cells from growing.
Do NOT use sorafenib if:
you are allergic to any ingredient in sorafenib
you have a certain type of irregular heartbeat (congenital long QT
you have a certain type of lung cancer (squamous cell) and are
taking carboplatin and paclitaxel
Contact your doctor or health care provider right away if any of
these apply to you.
Before using sorafenib:
Some medical conditions may interact with sorafenib. Tell your
doctor or pharmacist if you have any medical conditions, especially
if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are
if you are able to become pregnant
if you are taking any prescription or nonprescription medicine,
herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
you have heart failure or other heart problems (eg, irregular
heartbeat, disease of the blood vessels in the heart, a recent
if you have chest pain; high blood pressure; bleeding problems;
blood electrolyte problems (eg, low blood calcium, magnesium, or
potassium levels); stomach or bowel problems (eg, tearing); or
liver, kidney, or thyroid problems
if you have or are being treated for lung cancer
if you have recently had or will be having surgery
if you take any medicine that may increase the risk of a certain
type of irregular heartbeat (prolonged QT interval). Check with
your doctor or pharmacist if you are unsure if any of your
medicines may increase the risk of this type of irregular heartbeat
Some MEDICINES MAY INTERACT with sorafenib. Tell your health care
provider if you are taking any other medicines, especially any of
Warfarin because risk of bleeding may be increased
Carbamazepine, dexamethasone, hydantoins (eg, fosphenytoin,
phenytoin), nevirapine, oral neomycin, phenobarbital, primidone,
rifamycins (eg, rifabutin, rifampin), or St. John's wort because
they may decrease sorafenib's effectiveness
This may not be a complete list of all interactions that may occur.
Ask your health care provider if sorafenib may interact with other
medicines that you take. Check with your health care provider
before you start, stop, or change the dose of any medicine.
How to use sorafenib:
Use sorafenib as directed by your doctor. Check the label on the
medicine for exact dosing instructions.
An extra patient leaflet is available with sorafenib. Talk to your
pharmacist if you have questions about this information.
Take sorafenib on an empty stomach at least 1 hour before or 2
hours after eating.
Swallow sorafenib whole. Do not break, crush, or chew before
Take sorafenib with a full glass of water (8 oz [240 mL]).
Continue to take sorafenib even if you feel well. Do not miss any
If you miss a dose of sorafenib, skip the missed dose and go back
to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how
to use sorafenib.
1. Rich experience.
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in pharmaceutical area of many years, our products have exported to
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