Finasteride Pharmaceutical Intermediates Anti-androgen Medication
Finasteride CAS NO.: 98319-26-7
Molecular Formula: C20H24O2
Molecular weight: 372.54
Appearance:white crystalline solid
Usage: for the treatment of benign prostatic hyperplasia (BPH) and
male pattern baldness (MPB)
Finasteride: Proscar; Prostide; Raw Powder; Baldness Treatment;
Treat Hair Loss; Pharmaceutical Raw Materials
Finasteride is a popular anti-androgen medication manufactured by
Merck most commonly known as either Proscar or Propecia. Based on
the progesterone skeleton, Finasteride belongs to a class of
medications known as 5alpha-reductase inhibitors and as such is
used for the treatment revolving around type 2 5-AR based
This is important for performance enhancers as DHT based anabolic
steroids have specific side-effects that may occur that can largely
be remedied with the use of a 5-AR inhibitor such as Finasteride.
As a type 2 5-AR inhibitor Finasteride was designed for the purpose
of treating hair-loss, prostate enlargement, as well as prostate
Finasteride is very common among those who supplement with anabolic
steroids yet fear hair-loss but there are important things you need
to understand before you consider Finasteride use. As an androgen
suppressor Finasteride can seriously inhibit the gains made while
on cycle, severely and on that basis it is not highly recommended
for on-cycle hair preservation.
Propecia (finasteride) is used to treat male pattern baldness
(androgenic alopecia) in men. Topically (on the scalp itself) it is
of some effect in minimizing further hair loss. In combination with
Nizoral and spironolactone (which smells awful, by the way) it can
actually reverse loss moderately.
Used for the treatment of prostate disease first. Clinical studies
suggest that, with finasteride 1 mg/day, continuous oral 3 months or slightly long can have hair growth, after
continuous treatment 1 year hair growth rate to 48%, and can continue to fall off, taking the hair
organization 2 years hair growth rate reached 66% ~ 83%.
Finasteride belongs to a class of medications known as
5alpha-reductase inhibitors and as such is used for the treatment
revolving around type 2 5-AR based occurrences.
(1) Benign prostatic hyperplasia:
Physicians use finasteride for the treatment of benign prostatic
hyperplasia (BPH), informally known as an enlarged prostate. The
FDA-approved dose is 5 mg once a day. Six months or more of
treatment with finasteride may be required to determine the
therapeutic results of treatment. If the drug is discontinued, any
therapeutic benefits reverse within about 6–8 months. Finasteride
may improve the symptoms associated with BPH such as difficulty
urinating, getting up during the night to urinate, hesitation at
the start of urination, and decreased urinary flow.
(2) Male pattern baldness:
Three Phase 3 clinical trials examined the efficacy of finasteride
in the treatment of mild to moderate male pattern baldness. The
primary endpoints of each trial were hair count and user
self-assessment. Secondary endpoints included investigator
assessment and examination of scalp photographs. Each patient also
filled out questionairres regarding sexual health and non-scalp
body hair growth. These trials enrolled 1879 men and had a duration
of one year. Of these 1879 men, 1215 elected to participate in a
one year double blind extension trial. Additional extension trials
were performed such that 323 men experienced over 4 years of
Across all three trials, at one year men taking Propecia had 107
more hairs per 1 inch diameter section of scalp (in the area
affected by hair loss) than men treated with placebo. At two years
the difference was 138 hairs. Maximum hair gain occurred during the
first two years, but because hair loss was more rapid in the
placebo treated group, the difference between treated and placebo
groups increased to 277 hairs per inch circle at 5 years. Self
assessment showed that treated patients perceived an improvement in
hair density and overall appearance. These results were supported
by investigator ratings and by independent readers examining scalp
At the end of the first year, the sexual health questionaire
revealed differences in sexual interest, erections, and perception
of sexual problems that favored the placebo group. However, no
significant difference was seen in the question on overall
satisfaction with sex life.
Finasteride is sometimes used in hormone replacement therapy for
male-to-female transsexuals in combination with a form of estrogen
due to its antiandrogen properties. However, little clinical
research of finasteride use for this purpose has been conducted and
evidence of efficacy is limited. Indeed, finasteride is a
substantially weaker antiandrogen in comparison to conventional
antiandrogens like spironolactone and cyproterone acetate.
White or off-white crystalline powder
Off-white crystalline powder
Matches with working standard
Freely soluble in chloroform and in alcohol; Very slightly soluble
Residue on ignition
The specification conform with Enterprise standard
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