Healthy 99% Pharmaceutical Intermediates Orlistat for Weight Loss
More details about Orlistat:
Appearance: White powder
Package: foil bag
Orlistat blocks some of the fat that you eat, keeping it from being
absorbed by your body.
Orlistat is used to aid in weight loss, or to help reduce the risk
of regaining weight already lost. This medicine must be used together with a reduced-calorie diet.
Orlistat is for use only in adults.It is dangerous to purchase
orlistat on the Internet or from vendors
outside of the United States. Medications distributed from Internet
sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of "alli"
purchased on the Internet have been found to contain sibutramine (Meridia), a prescription weight loss
medication that can have dangerous side effects in certain people. For more information, contact the U.S. Food and
Drug Administration (FDA) or visit .
Orlistat (also known as tetrahydrolipstatin) is a drug designed to
treat obesity. It is marketed as a prescription drug under the
trade name Xenical by Roche in most countries, and is sold
over-the-counter as Alli by GlaxoSmithKline in the United Kingdom
and the United States. Its primary function is preventing the
absorption of fats from the human diet by acting as a lipase
inhibitor, thereby reducing caloric intake. It is intended for use
in conjunction with a healthcare provider-supervised
Orlistat is the saturated derivative of lipstatin, a potent natural
inhibitor of pancreatic lipases isolated from the bacterium
Streptomyces toxytricini. However, due to its relative simplicity
and stability, orlistat was chosen over lipstatin for development
as an anti-obesity drug.
(1) Orlistat is used for the treatment of obesity. The amount of
weight loss achieved with orlistat varies. In one-year clinical
trials, between 35.5% and 54.8% of subjects achieved a 5% or
greater decrease in body mass, although not all of this mass was
necessarily fat. Between 16.4% and 24.8% achieved at least a 10%
decrease in body fat. After orlistat was stopped, a significant
number of subjects regained weight—up to 35% of the weight they had
(2) The incidence of type 2 diabetes in an obese population over
four years is decreased with orlistat (6.2%) compared to placebo
(9.0%). Long-term use of orlistat also leads to a modest reduction
in blood pressure (mean reductions of 2.5 and 1.9 mmHg in systolic
and diastolic blood pressure respectively).
The effectiveness of orlistat in promoting weight loss is definite,
though modest. Pooled data from clinical trials suggest that people
given orlistat in addition to lifestyle modifications, such as diet
and exercise, lose about 2–3 kilograms (4.4–6.6 lb) more than those
not taking the drug over the course of a year.Orlistat also
modestly reduces blood pressure, and appears to prevent the onset
of type 2 diabetes, whether due to weight loss itself or to other
effects; in a large randomized controlled trial, orlistat was found
to reduce the incidence of diabetes by nearly 40% in obese people.
Orlistat is notorious for its gastrointestinal side effects
(sometimes referred to as treatment effects), which can include
steatorrhea (oily, loose stools). These decrease with time,
however, and are the most frequently reported adverse effects of
the drug. In the United States and the European Union, orlistat is
available for sale without a prescription. Over-the-counter
approval was controversial in the United States, with consumer
advocacy group Public Citizen repeatedly opposing it on safety and
efficacy grounds. Generic formulations of orlistat are available in
some countries. A prescription is needed for use in Australia.
Certificate Of Analysis (COA)
white or almost white crystalline powder,smell less
The result of HPLC is consisitent to the reference one. The result
of IR is consisitent to the reference one.
Residual on Ignition
≤ 99.0% ~ 99.9%
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