73-78-9 Local Anesthetic Drugs Lidocaine Hydrochloride
Pharmaceutical Steroids Powder
Product name: Lidocaine Hydrochloride
Other name: Lidocaine HCL, Lidocaine, Lidocaine Base
Melting point: 350.8° C at 760 mmHg
Usage: Local anesthetics, antiarrhythmic drugs, used for a variety
of anesthesia and rapid ventricular arrhythmia
Lidocaine may be absorbed following topical administration to
mucous membranes, its rate and extent of absorption depending upon
concentration and total dose administered, the specific site of
application, and duration of exposure. In general, the rate of
absorption of local anesthetic agents following topical application
occurs most rapidly after intratracheal administration. Lidocaine
is also well-absorbed from the gastrointestinal tract, but little
intact drug may appear in the circulation because of
biotransformation in the liver.
Lidocaine is metabolized rapidly by the liver, and metabolites and
unchanged drug are excreted by the kidneys. Biotransformation
includes oxidative N-dealkylation, ring hydroxylation, cleavage of
the amide linkage, and conjugation. N-dealkylation, a major pathway
of biotransformation, yields the metabolites
monoethylglycinexylidide and glycinexylidide.
The plasma binding of lidocaine is dependent on drug concentration,
and the fraction bound decreases with increasing concentration. At
concentrations of 1 to 4 mcg of free base per mL, 60 to 80 percent
of lidocaine is protein bound. Binding is also dependent on the
plasma concentration of the alpha-1-acid glycoprotein.
White crystalline powder
99.0% to 101.0%
Clear and colorless
Single unspecified impurity: ≤0.1%
Total impurity: ≤0.5%
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